![]() Fibroblast cells are the cells needed to hold skin and other connective tissue together. The virus was then "grown" in human embryo fibroblast cells. The family name of the child was Oka, and the strain of vaccine virus is now called the "Oka" strain. Natural varicella virus was first taken from a young child infected with varicella in Japan. Natural varicella virus reproduces itself thousands of times, occasionally causing severe disease, and is then passed on to the next person unchanged.īut the process of "cell-culture adaptation" changes all of that. Cells are the building blocks of all the different parts of the body, like skin, heart, muscles and lungs. Natural varicella virus normally grows in cells that line the skin or the back of the throat. "Cell-culture adaptation" modifies natural varicella virus so that it behaves very differently once it is injected into the body. The varicella vaccine virus is "weakened" by a process called "cell-culture adaptation." ( see "How Are Vaccines Made?"). Like the MMR vaccine, the varicella vaccine is a live, "weakened" form of natural varicella virus. If 100 people are sitting in a room together for several hours talking and one of them has chickenpox and the other 99 have never been infected with chickenpox or vaccinated with the chickenpox vaccine, about 85 of the remaining 99 will get chickenpox. How contagious is chickenpox?Ĭhickenpox is very contagious. Finally, a bacterium called Group A streptococcus, commonly known as "flesh-eating" bacteria, can enter through the skin during a varicella infection and cause severe, and sometimes fatal, disease. These birth defects include developmental delay and shortened or atrophied limbs. In addition, about 1 of every 50 women infected with varicella during their pregnancy will deliver children with birth defects. About 1 of every 1,000 children infected with varicella will develop severe pneumonia (infection of the lungs) or encephalitis (infection of the brain). ![]() However, chickenpox infections can have severe complications. As many as 300-500 blisters can occur during a single infection.Ĭhickenpox is usually a relatively benign infection. ![]() The rash of chickenpox begins as red bumps that turn into blisters that cover the entire body. It can spread in one of three ways: by coughing or sneezing, physical contact with broken blisters, or by virus particles from the blisters that are sprayed in the air. Portions of this document last updated: Sept.Chickenpox is an infection caused by the varicella virus, and it is highly contagious. You may report side effects to the FDA at 1-80. If you notice any other effects, check with your healthcare professional.Ĭall your doctor for medical advice about side effects. Other side effects not listed may also occur in some patients. Red rash with watery, yellow-colored, or pus-filled blisters Pain, redness, swelling, tenderness, or warmth on the skin Hives, itching, pain, redness, soreness, tenderness, or warmth at the injection siteīurning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More commonįever of 37.7☌ (100☏) or higher, but not above 39☌ (102☏) Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Some side effects may occur that usually do not need medical attention. Weakness in the arm or leg on one side of the body, sudden and severe Unsteadiness, trembling, or other problems with muscle control or coordination Sudden numbness and weakness in the arms and legs Sores, ulcers, or white spots in the mouth or on the lips Red skin lesions, often with a purple center Raised red swellings on the skin, buttocks, legs, or ankles Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue Painful blisters on the trunk of the body Muscle spasm or jerking of all extremities Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs Large, flat, blue, or purplish patches in the skin Unusual tiredness or weakness, sudden and severeīlistering, peeling, or loosening of the skinīloating or swelling of the face, arms, hands, lower legs, or feet ![]() Reddening of the skin, especially around the ears Swelling of the ankles, face, fingers, feet, or lower legs Check with your doctor immediately if any of the following side effects occur: More commonĬoughing that sometimes produces a pink frothy sputum
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